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Main
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Groups
- Molecular Oncology
- Translational Oncology
- Tumour Biology
- Medical Oncology
- Skin Tumour
- Epidemiology, Mathematics & Statistics
- Nuclear Medicine
Associated
Bodies
- Cancer Research
UK
- Queen Mary University of London
- Queen Mary School
of Medicine & Dentistry
- Barts
& The London NHS Trust
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Vision for the Centre:
A molecular approach to the problem of cancer in patients and
populations
The Barts-London Centre as the largest constellation of
CR-UK clinical and translational groups in London. Over thirty principal
investigators have come together to develop a coordinated molecular and
cellular approach to the problem of cancer in patients and populations.
The Centre concept enables us to rationalise resources, improve the use
of major equipment, establish coordinated biological service facilities,
share technology platforms and technical expertise, and develop new translational
research programmes.
The strategy of the Clinical Centre will be built on an integrated molecular
and cellular approach to the problem of cancer in patients and populations.
It will cover a spectrum of molecular and genetic research for target
identification in haematological and solid malignancies (gynaecological,
breast, skin, pancreatic and prostatic); cell biology and genetic reconstruction
models (keratinocyte, breast and pancreatic); cancer epidemiology, screening
and intervention; targeting, imaging and therapy of cancer.
The Centre is physically close to Cancer Research UK's London Research
Institute at Lincoln’s Inn Fields and thus is in an ideal geographical
position to develop a special relationship of benefit to each partner.
The potential for rapid development of translational programmes will be
actively promoted at all levels in the organisation.
Genomics research is strong in the Barts-London Centre and is underpinned
by core facilities in molecular pathology and proteomics to interface
with both patient-based and population-based applications. The Barts-London
Centre has well coordinated support facilities - particularly imaging
and tissue-based resources, and centralised equipment parks.
Key developments in the Centre:
Molecular Pathology
A state of the art Molecular Pathology Facility including genomics, transcriptomics
and proteomics, flow cytometry and molecular imaging. The Centre provides
- full Affymetrix microarray support with an embedded bioinformatics
group
- laser-assisted microdissection and tissue microarray technology, as
well as reagent development for clinical applications
- automated processing and hybridisation technology with Ventana Discovery
platform
- confocal and digital microscopy suites with research histopathology
expertise
Molecular Oncology and Stem Cell Biology
- Innovative programmes in target identification and treatment development
in epithelial and haematological malignancies. The Centre brings together
groups working on cell survival, cytokine networks and migration signalling
as well as gene therapy for cancer on the Charterhouse campus.
- World-renowned programmes in keratinocyte and gastrointestinal cell
biology linked to the Adult Stem Cell Biology Centre, concentrated at
the new Institute of Cell & Molecular Sciences on the Whitechapel
campus.
Imaging and targeting
- The Centre is building on the successful activities of the Nuclear
Medicine Group to expand into novel molecular imaging technologies to
interface with the programmes in cell biology and experimental therapeutics.
Epidemiology, Screening and Intervention
- The Centre is developing molecular pathology platforms to support
population-based epidemiology studies with particular focus on virus-related
cancers.
- A clinical trial methods group is established with relationships between
the oncology therapeutics programme and the Wolfson Institute of Preventive
Medicine.
Early phase clinical trials of novel therapeutics
- An early phase clinical trials group has been established, with special
emphasis on gene and viral therapies. The Clinical Research Centre in
Barts & The London Trust is developing as a robust and reactive
resource enabling investigators to fulfil the vision of translating
discoveries to patient benefit.
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