Skin
Tumour
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Skin
Tumour
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Main Groups Associated
Bodies |
Skin Tumour Laboratory Cancer Research UK Skin Tumour Laboratory Please also see the Centre for Cutaneous Research's web pages at the
Barts and The London, Queen Mary's School of Medicine and Dentistry. The Skin Tumour Laboratory (STL) is part of the Centre for Cutaneous Research, in the Institute Cellular and Molecular Science, on the Whitechapel campus of Barts and the London, Queen Mary's University of London .Research in the unit is exploring the fundamental hypothesis that cutaneous human papillomaviruses (EV-HPV) co-operate with u ltraviolet radiation in the development of cutaneous sqamous cell carcinomas by altering the balance between proliferation and cell death through blockade of UV-induced apoptosis; that there is a hierarchy of oncogenicity in contributory viruses, which may be reflected in genetic changes in tumours and that a better understanding of the viral-host interaction is leading to targeted therapeutic and preventative strategies in high-risk individuals The HPV and cancer group seeks to better understand the role of cutaneous HPV in NMSC development and finding that Bak, an apoptogenic member of the Bcl-2 family, is activated and stabilised in the skin by UV and is targeted for proteolysis by HPV E6 proteins, has proposed a new model of Bak activation. The epithelial differentiation group is studying the role of AKT kinases in epidermal development and differentiation. These kinases are targeted by cutaneous HPV and misregulated during epidermal tumourigenesis..
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