London Research Institute
-Clare Hall Laboratories-
-Cancer Research UK-
Charity Registration No. 1089464 -Terms and Conditions-
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Molecular Enzymology
London Research Institute -Clare Hall Laboratories- -Cancer Research UK- Charity Registration No. 1089464 -Terms and Conditions- |
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| PcrA helicase substrate complex |
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PcrA.DNA.ADPNP Detail of duplex DNA binding site.
 The protein has been rotated by about 90o so that you are now viewing the complex looking straight at the duplex DNA binding site. The single stranded DNA is running into the protein and away from the screen. The five base pairs nearest the ss/dsDNA junction are distorted and already partially unwound. Note that in this region the protein is negatively charged (red). Further away from the junction the protein surface is positively charged and creates a good binding surface for B-form DNA. |